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routineHealthcare & BiomedicalResNet-50 with PQC sidecar2608.22475

Quantum-Inspired Hybrid Neural Networks for Neural Decoding: A Controlled Ablation Study of Learnable Quantum Sidecar Integration

Diana Legziel Levy, Menachem Finkelstein, Peter Chin, Eilon Vaadia, Sarel Cohen

cs.LG quant-ph

Abstract

We study parameterized quantum circuits (PQCs) integrated as residual sidecar modules within a ResNet-50 backbone for 31-class neural population decoding---imagined handwriting classification from multi-neuron spike rasters. Under strictly controlled conditions (fixed data splits, seeds, and optimizer), we compare four model variants: baseline, quantum sidecar with frozen input projection, quantum sidecar with backbone-gradient-trained projection, and a measurement-guided variant that aligns angle encodings with circuit measurement outcomes. The backbone-gradient variant improves accuracy in 3/4 seeds (+0.19% mean, 95% CI [-1.10%, +1.48%]) and consistently reduces Linear CKA similarity to baseline features ($Δ=-0.025$, 4/4 seeds), indicating genuine structural reorganization of representations. A nine-variant ablation identifies simple shallow architectures as the most effective and reproducible configuration. Measurement-guided training consistently improves representation geometry without reducing accuracy. All results use noiseless statevector simulation on 4 qubits, a regime chosen to reflect the practical constraints of current near-term superconducting hardware; no quantum computational advantage over classical methods is claimed.

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Classified with taxonomy v2 on Sat, 5 Sept 2026.

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