Histopathological subtyping relies on the recognition of characteristic histological patterns. These patterns may be expressed by individual tissue structures or by the spatial distribution and co-occurrence of multiple structures, and they often span irregularly shaped tissue regions, termed semantic units in this work. However, conventional patch-based representations may fragment such units and fail to explicitly preserve their internal spatial organization, while efficiently modeling relationships among numerous spatially separated units remains challenging. To address these limitations, we propose the Semantic-Aware Subgraph State Space Model (SASG-SSM), a flexible and efficient framework for whole slide image (WSI) classification. Semantic-Aware Subgraphs (SASGs) first approximate irregularly shaped semantic units by adaptively grouping spatially connected patches guided by class-agnostic visual-semantic priors. By representing patches as graph nodes with adjacency edges, SASGs preserve their internal spatial organization rather than treating them as an unordered set. A Subgraph State Space Module (SG-SSM) subsequently combines a graph neural network encoder for intra-subgraph topology encoding with a Mamba-based state space encoder for efficient contextualization across large numbers of subgraphs. This module integrates local structural information within semantic units with global contextual information arising from their distribution and co-occurrence across the WSI, while efficiently modeling a large number of spatially distributed regions. Extensive experiments across four WSI subtyping datasets demonstrate consistent advantages over representative state-of-the-art methods. Further evaluations under small-cohort and few-shot settings demonstrate robustness and data efficiency under limited training data. Code will be released at https://github.com/HLSvois/SASG-SSM.
Deep snake is a promising family of instance segmentation methods that accurately predicts object-level contours, thereby overcoming common pixel-level misclassification issues such as mask cavities and jagged edges in semantic segmentation approaches. However, existing deep snake methods face challenges in handling complex morphological variations, accurately capturing fine-grained organ details, and correcting base detection errors. To mitigate these limitations, we propose a cohesive Text-prompted spatiotEmporal dual-heAd Mamba Snake (TEAMS), a novel vision-language Mamba snake framework with three key innovations: (1) A Spatiotemporal Snake Evolution Strategy (SSES) is introduced to tackle complex morphological variations by capturing bidirectional spatial dependencies along the snake contour and temporal dynamics across evolution steps in a state space model. (2) A Contour Morphology-Aware Mamba (CMAM) is proposed to quantify local contour morphologies to modulate the structured attention mask in the Mamba2 SSD dual form, which extends Mamba's capability to perceive the relative importance of its input sequence elements for better delineation of fine-grained organ details. (3) A Text-prompted Collaborative Dual-Head Snake (TCDHS) is designed to incorporate cues from textual prompts and transfer the evolved contour information to the base detection head, which enhances the deep snake workflow and mitigates wrong detections. Comprehensive evaluations on five datasets covering different organs and imaging modalities demonstrate that TEAMS outperforms existing semantic and deep snake segmentation methods (e.g., relative mDice/mBF improvements of 6.9%/9.1% in a spinal dataset), underscoring its potential as a reliable tool across diverse medical image segmentation scenarios.
Remote photoplethysmography (rPPG) enables non-contact heart rate (HR) monitoring from facial videos, but RGB-only methods are vulnerable to illumination changes, motion artifacts, and skin-tone-dependent optical reflectance. We propose CardiacMamba, a fair and robust RGB-RF fusion framework that integrates optical facial cues and radio-frequency cardiac motion cues through state space modeling. CardiacMamba introduces a Temporal Difference Mamba Module (TDMM) to enhance subtle RF temporal variations, a bidirectional SSM-based interaction mechanism to align heterogeneous RGB-RF dynamics, and a Channel-wise Fast Fourier Transform (CFFT) module for channel-domain spectral refinement. On the EquiPleth dataset, CardiacMamba achieves state-of-the-art performance with 0.96 bpm MAE, 3.06 bpm RMSE, and 0.97 Pearson correlation, while reducing the observed light-dark skin-tone MAE gap to 0.26 bpm and maintaining robustness under RGB degradation and RF-missing conditions
Encoder-decoder imbalance and the reliance on large input volumes make many 3D brain tumor segmentation models both compute-heavy and brittle. We present M\textsuperscript{4}Fuse, a lightweight network that prioritizes discriminative brain tumor cues over exhaustive appearance reconstruction. Our method balances encoder and decoder capacity and replaces depth expansion with a synergistic design: it propagates long-range context with linear complexity via a grouped state space mixer, denoises and aligns skip features using a cross-scale dual-stage gating bridge, and absorbs cross-site acquisition shifts with a sample-level mixture-of-experts. On the BraTS2019 and BraTS2021 benchmarks, M\textsuperscript{4}Fuse outperforms other lightweight excellent methods in both parameter count and performance. Even at a challenging input resolution of \(64\times128\times128\) (half that of existing excellent models), M\textsuperscript{4}Fuse reduces parameters by 62.63\% and improves average performance by 0.09\%. Ablations of key components validate the method's exceptional parameter-to-accuracy efficiency and robustness across diverse data centers.